Post-doctoral Position Offer
on the March 5, 2019
Background
Heparan Sulfate (HS) are highly complex polysaccharides, ubiquitously present on cell surfaces. They interacts with a large array of proteins (growth factors, cytokines, chemokines, signaling receptors, enzymes, adhesion molecules, pathogens…), thereby controlling most major biological processes (cell proliferation, migration, chemoattraction, angiogenesis, immune responses, viral infection or matrix assembly). Whereas it has been well established that these interactions occur through defined saccharide epitopes present within the polysaccharide chain, the mechanism by which these binding sequences are specifically assembled remains enigmatic.
Objective
- Produce and purify the enzymes involved in HS biosynthesis and identify their interactions.
- Develop and use assays to follow the enzyme/enzyme complex catalytic activities.
- Characterize the HS sequences synthesized by these different complexes.
- Participate in a collaborative network (Dr. Y. Bourne - AFMB, Marseille; Dr. G. Schoehn – IBS, Grenoble) to solve the structures of the enzymes/enzyme complex complexes.
- Write scientific publications to international journals and present results at national and international meetings.
Candidate profile
Application
If you meet these requirements and wish to contribute to this project, please send your application to Hugues Lortat-Jacob (Hugues.Lortat-Jacob@ibs.fr). The Application shall comprise the following documents, assembled into a single PDF file: a cover letter of interest detailing your motivation for applying, along with the names and contact information of at least two scientists to whom letter of recommendation can be sought, a curriculum vitae with a full publication list and a brief report (maximum 2 pages) on your previous research including a description of your background and expertise.
Review of completed applications will begin January 2019, and continue until the position is filled.
The host institute
The IBS is a French academic research unit, affiliated with the University Grenoble-Alpes, the CNRS and the CEA. It currently employs 280 people, including many students and post-doctoral researchers originating from different countries. It possesses high-performance internationally competitive facilities in molecular and cellular biology, biochemistry, biophysics and structural biology. The Institute is a founding member of the Partnership for Structural Biology together with prestigious pan-European institutes: the European synchrotron X-ray source, the European center for neutron scattering, the Grenoble Outstation of the EMBL, located nearby and providing a strong international environment.
Grenoble is a pleasant city situated in the French Alps and is one of the most renowned scientific area in France for biological studies.