Thesis defense: Bastien MICHEL

on the December 3, 2021

Friday, december 3rd, 9:00 am
Room D2, LGP2/Pagora
Bastien MICHEL, from LGP2 and NTNU, will defend his thesis entitled: "Cyclodextrin-functionalized nanocellulose for biomedical applications".


The purpose of this project is to combine oxidized cellulose nanofibrils (toCNFs) and various β-cyclodextrins (β-CDs) to design improved materials for biomedical applications. The combination of toCNFs and β-CDs, although promising, faces some challenges, notably characterization of this association. Thus, this project aims at developing innovative materials combining toCNF and various β-CD derivatives, with the objective of characterizing the adsorption phenomena and improving drug release of poorly-water soluble active principal ingredient (API) and consequently prolonging antimicrobial properties. First, the production of toCNF/β-CD materials was reported, with an investigation on the impact of various process parameters on water sorption and mechanical properties. The adsorption of β-CDs was characterized via different experimental tools, and it was shown that β-CD derivatives adsorb up to 10 times more onto toCNF than β-CD. The formation of an inclusion complex between a model API and the various β-CDs was thoroughly characterized. Finally, the functionalization of toCNF with β-CDs showed improvement of the antimicrobial properties of films with increased efficiency for carboxymethylated-β-CD. The results of this project contribute to the knowledge on interaction of cyclodextrin and nanocellulosic materials and are a step-towards their efficient application in biomedical field as well as other applications such as depollution.

Directors: Alain Dufresne (Dir. de thèse, LGP2), Julien Bras (Co-dir de thèse, LGP2), Kristin Syverud (Co-encadrante, NTNU/RISE PFI, Norway), Ellinor B. Heggset (co-encadrante,RISE PFI, Norway).

Jury: Bernard Cathala (Dir. de recherche,INRAE Nantes), Naceur Belgacem (Pr., Grenoble INP), Carmen Freire (Senior researcher, U.Aveiro), Sophie Fourmentin (Pr., ULCO)


Published on November 22, 2021

Practical informations


Friday, December 3rd, 2021, 9:00am

Room D2
461 Rue de la Papeterie
38610 Gières