Work-package 2 will use all chemical and biological tools to produce bioactive glycans and explore their roles as biomarkers and therapeutics. WP2 aims at a better understanding of the biochemical pathways of glycan biosynthesis and assembly and use of the knowledge of their function to develop personalized medical care.
Objectives
to decipher the glycocode on cell surface and plant, fungal and bacterial cell walls
to understand the complexity of protein-glycan interactions and their implications in health and diseases
to exploit this knowledge for applications in biotechnology and health.
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Description of the work
Task 1: Characterization of new glycoenzymes and glycoreceptors.
Task 2: Design and synthesis of new glycomolecules, scaffolds and nano-objects.
Task 3: Design of glycotools for diagnosis and therapeutic applications.
International collaboration
CEITEC Brno
Napoli Univ
CIC bioGUNE Bilbao and CIC biomaGUNE San Sebastian
